Bio-electronic interfaces is a multidisciplinary research field dedicated to understanding, designing, and implementing the interaction and communication between biological systems and electronic devices. This concept centers on the bidirectional transduction of signals between biological processes and electronic signals, spanning from single cells to complex organisms. Key to this field are the development of compatible materials and architectures for seamless structural and functional integration with living tissues, the engineering of sensitive sensors and actuators, and the exploration of biomimetic and biohybrid strategies. Its significance lies in enabling transformative applications in areas such as biosensing, neural interfaces, medical devices, and synthetic biology through the creation of functional connections between living and artificial systems.